To elucidate the genetic mechanisms underlying the antibiotic resistance and the evolved phenotypes in the evolved CIP-resistant colonies, we have sequenced 24 CIP-resistant colonies recovered from CIP-evolved populations (16 colonies isolated from biofilm populations and 8 colonies isolated from planktonic populations) and 18 CIP-resistant colonies recovered from CTRL-evolved populations (11 colonies isolated from biofilm populations and 7 colonies isolated from planktonic populations) for both WT PAO1 and ΔkatA. The genomic DNA of original ancestors PAO1 and ΔkatA were sequenced as well. This evidence concerns the gene SMOX and hereditary sensory and autonomic neuropathy.