MOG-AAD exhibits an age-related array of clinical phenotypes ranging from acute disseminated encephalomyelitis (ADEM), clinically isolated syndrome (CIS), optic neuritis (ON), recurrent forms of ADEM and ON, transverse myelitis (TM) and neuromyelitis spectrum disorder (NMO-SD)2,3,5,6. Here, MOG is linked to acute disseminated encephalomyelitis.