KRAS and colorectal carcinoma: Consistent with this, we found that KRAS-mutated CRC cells (HCT116 and DLD-1) had a significant increase in fluorescence ratio using crisp-17 compared to wild-type KRAS cells (CACO-2), upon addition of DTDP, suggesting elevated intracellular labile Cu pools in the KRAS-mutant cells (Fig. 3g).