UWB.289/BRCA1+/−44 and UWB.289/53BP1−/− were developed from BRCA1MUT UWB.289 primary tumor cultures (derived from a gBRCA1MUT HGSOC patient) and demonstrated an increase an IC50 about 83-fold and 4-fold, respectively, compared with UWB.289 parental (Supplementary Fig. 1a, e). Here, BRCA1 is linked to neoplasm.