Lee et al. showed that AIMP2 accumulation overactivated poly(ADP-ribose) polymerase-1 (PARP1), resulting in the PAR accumulation and progressive loss of dopaminergic neurons, suggesting that AIMP2-induced parthanatos contributed to dopaminergic cell death, and that PARP1 inhibitors might be used to delay the progression of Parkinson’s disease (PD)43. Here, AIMP2 is linked to Parkinson disease.