CD4 and autoimmune disease: The increased proportion of CD5high cells among Egr2/3−/− MP CD4 T cells (Fig 6A and B), and auto-reactive T cells and autoimmune disease in CD2-Egr2/3−/− mice (Li et al, 2012; Morita et al, 2016) suggests that these enriched clones may have high affinity for self-antigen.