Impaired T-cell receptor–mediated proliferation and hyper-inflammation of MP CD4 T cells have also been found in SLE and RA patients (Cope, 2004; Crispin et al, 2017) further indicating that maintenance of MP T-cell homeostasis is essential for both preventing autoimmunity and supporting adaptive immune responses. This evidence concerns the gene CD4 and systemic lupus erythematosus.