We have also previously observed that Egr2−/− MP CD4 T cells in old CD2- Egr2−/− mice, which are also prone to develop autoimmunity (Zhu et al, 2008; Miao et al, 2013), have increased homeostatic proliferation (Zhu et al, 2008). This evidence concerns the gene EGR2 and Autoimmunity.