In another study, we showed that the MUC16 C-terminal region (283 amino acids of C-terminus) was responsible for increasing the tumorigenic and metastatic potential of PC cells by promoting the JAK2/STAT3 pathway, that results in upregulation of LMO2 and NANOG genes (Das et al., 2015). This evidence concerns the gene STAT3 and pachyonychia congenita.