The major risk factors for PDAC initiation and progression include genetic mutations in KRAS, INK4A (p16), Trp53, DPC4 and BRCA2 as well as other risk factors like cigarette smoking, obesity and diabetes mellitus (Guerra et al., 2007; Habbe et al., 2008; Hingorani et al., 2003; Jones et al., 2008). Here, CDKN2A is linked to obesity due to melanocortin 4 receptor deficiency.