The sympathoexcitation induced by oxidative stress in the RVLM has been shown to play a crucial role in causing blood pressure elevation in a number of hypertension models, including obesity-induced hypertension [91], neurogenic hypertension [92], angiotensin II (AngII)-induced hypertension [93] as well as in the spontaneously hypertensive rats [94]. The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.