PPARG and hyperinsulinism: Particularly, insulin resistance is associated with hyperinsulinemia [7, 8], increased levels of insulin-like growth factors (IGF) [9, 10], and alterations in necrosis factor (NF)-κB [11] and peroxisome proliferator-activated receptor gamma (PPARγ) signaling [12], which plays a key role in the pathogenesis of CRC [13–15].