Mice with oncogenic Kras expressed in acinar cells and deficient in pigment epithelium-derived factor (PEDF) showed a significant increase in intrapancreatic adipocytes, which was associated with a higher degree of ADMs, more frequently occurring cystic papillary neoplasms, and an increased incidence of invasive and metastatic PDAC [138]. This evidence concerns the gene SERPINF1 and papillary cystic neoplasm.