Hence, to better understand the efficacy of the combined treatment with QU and CP and effects of QU/CP interactions on tumor growth, we performed a multimodal study in in vitro and in vivo systems under physiological and hyperthermic conditions, which mimic intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) condition when the tumor is in an advanced stage of growth. This evidence concerns the gene CP and neoplasm.