Interestingly, MMP2, MMP9 and MMP13 levels were increased in sEVs derived from hypoxic prostate cancer cells and hypoxic nasopharyngeal carcinoma cells [35,36] and exosomal MMP13 has been shown to enhance migration and invasion of recipient cells in vitro and in vivo [36]. The gene discussed is MMP13; the disease is prostate carcinoma.