In this context, hypoxic sEVs from melanoma cells exhibited a signature consisting of 6 proteins (Aldo-Keto reductase family 7 member A2 (AKR7A2) and DExD-Box Helicase 39B (DDX39B), eukaryotic translation initiation factor 3 subunit C (EIF3C), phenylalanyl-tRNA synthetase subunit alpha (FARSA), protein arginine methyltransferase 5 (PRMT5) and valyl-tNRA synthetase (VARS)), which were significantly associated with a poor prognosis for melanoma patients [22]. This evidence concerns the gene PRMT5 and melanoma.