Interestingly, MMP2, MMP9 and MMP13 levels were increased in sEVs derived from hypoxic prostate cancer cells and hypoxic nasopharyngeal carcinoma cells [35,36] and exosomal MMP13 has been shown to enhance migration and invasion of recipient cells in vitro and in vivo [36]. This evidence concerns the gene MMP13 and Familial prostate cancer.