INS and obesity due to melanocortin 4 receptor deficiency: Moreover, the state of insulin resistance in obesity is promoted by disorders in modulation of the processes of secretion and degradation of insulin (due to hypozincemia) [18,19], glycation of insulin [20], “leptin resistance” causing accumulation of triglycerides in muscle tissue [21,22,23] and disorders in secretion of neuropeptides [24].