Both miRNAs are also reported to have tumor suppressor activity; in particular, let-7e belongs to the large let-7 family of oncosuppressive miRNAs acting on key oncogenes, such as Ras and Myc [33], but also HMGA2, CDC25B in HCC [34], and indeed Lin28 [35]. This evidence concerns the gene HMGA2 and hepatocellular carcinoma.