Several genes responsible for the recruitment of melanoma cells (stabilin 1, ephrin receptor β4, and αv integrin), extracellular matrix remodeling (Mapk14, uPA, laminin 5, Col 18α1, G-α13, p38), vascular growth (TNF-α, TNF-αip2, VEGF-B, HIF-1α, Thbs1) [142], and effectors of pre-metastatic niche formation such as S100A8, S100A9 [74] were upregulated by B16-F10 MTEX. The gene discussed is MAPK14; the disease is melanoma.