While further work is required to understand the link between RAB29, LRRK2, and the etiology of PD, the present data highlight the possibility that, under more physiological conditions, RAB29 may be a positive regulator of non-Golgi-related membrane trafficking events impaired by pathogenic LRRK2, rather than controlling the localization and activation of LRRK2 at the Golgi complex. This evidence concerns the gene LRRK2 and Parkinson disease.