It has been suggested that METTL3 promotes bladder cancer cell proliferation and invasion by modulating pri-miR-221/222 [83] and the AF4/FMR2 family member 4 (AFF4)/nuclear factor kappa B subunit 1 (NF-κB)/MYC pathway in an m6A-dependent manner [84]. The gene discussed is NFKB1; the disease is urinary bladder cancer.