Similarly, the overexpression of METTL3 in colorectal cancer leads to abnormal m6A modification, and further promotes tumor progression and metastasis via its targets SOX2 [81] and the METTL3/miR-1246/Sprouty-related EVH1 domain containing 2 (SPRED2) axis [82], respectively. This evidence concerns the gene SPRED2 and neoplasm.