When viral genomic RNA is internalized and released into the cytoplasm after infection, the RNA is recognized by cellular RNA sensors such as stimulator of interferon response cGAMP interactor 1 (STING), Toll-like receptor 7 (TLR7), DExD/H-box helicase 58 (RIG-I), and others [122]. The gene discussed is RIGI; the disease is infection.