Another study showed that depletion of FTO destabilizes its critical mRNA targets such as ankyrin repeat and SOCS box containing 2 (ASB2) and retinoic acid receptor alpha (RARA) due to reduction in m6A levels at these targets, which are important for differentiation of acute myeloid leukemia (AML) cells [66]. Here, ASB2 is linked to acute myeloid leukemia.