By contrast, in the absence of caspase-8 following genetic ablation, pharmacological inhibition, or as a result of certain viral infections, RIPK1 and RIPK3 are stabilized and recruit mixed-lineage kinase domain-like protein (MLKL) into complex IIb, also known as necrosome, which initiates necroptosis [194,195]. The gene discussed is MLKL; the disease is viral infectious disease.