The notion of Sirt1 mediated negative regulation of T cell effector response was further strengthened by the observation that Sirt1 KO mouse showed the development of primary SLE like symptoms characterized by deposition of immune complexes within liver and kidneys, some even exhibited diabetes insipidus-like autoimmune disorder after 2 years of age [107]. The gene discussed is SIRT1; the disease is systemic lupus erythematosus.