FGF5 and Hypertension: Fibroblast growth factor (FGF) signaling plays an important role in endothelial homeostasis [10] even though there have not been many studies demonstrating direct interactions between blood pressure and FGF5. However, several previous genome-wide association studies (GWAS) have shown that the single nucleotide polymorphism (SNP) rs16998073 found in the FGF5 gene, a member of the FGF family, is strongly associated with hypertension in East Asians and Europeans [11,12,13].