Our study confirms similar reports about the effect of NFKBIE variants on NFkB activity in rheumatoid arthritis (RA) and lymphoid malignancies (chronic lymphocytic leukemia (CLL), primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (HL)) [41,42,43]. Here, NFKBIE is linked to B-cell chronic lymphocytic leukemia.