In spite of the diverse panel of strategies deployed by arenaviruses, it seems that the IFN antagonistic activities of NP are not sufficient to abolish the host innate immune response, as, in the context of infection by OW and NW, arenaviruses such as IFN-I and cytokine are still induced [100,125,126,127,128,129]. This evidence concerns the gene IFNA1 and infection.