NFKB1 and obesity due to melanocortin 4 receptor deficiency: Kim et al. [56] provided evidence of increased expression of TLR 1-9 and TLR 11-13 in murine adipose tissue in response to obesity induced by high-fat diet administration, causing activation of both MyD88- and non-MyD88 signaling cascades as well as downstream up-regulation of NF-kB activity and the subsequent release of adipokines.