NQO1 and Alzheimer disease: The first studies conducted between the late 90s and early 2000s demonstrated the ability of DMF to activate endogenous antioxidant defenses in neuronal cells that could counteract the damage produced by free radicals [106], in particular, increasing the production of the enzyme NAD(P)H quinone oxidoreductase 1 (NQO1), which exerts a neuroprotective function in hippocampal pyramidal neurons in AD patients [107,108].