DMF was able to attenuate neurotoxicity in in vitro model of 6-OHDA-stimulated SH-SY5Y cells and also in an animal model of Parkinson’s disease by enhancing Nrf2 activity and reducing the production of proinflammatory cytokines in splenocytes of mice as reported by Jing et al. [123]. The gene discussed is NFE2L2; the disease is Parkinson disease.