LGR5 and malignant colon neoplasm: In addition, these antitumoral effects were accompanied by a decrease in stem-cell markers, such as aldehyde dehydrogenase (ALDH) A (ALDHA), lin-28 homolog A (LIN28A), leucine rich repeat containing G protein-coupled receptor 5 (LGR5), and homeobox transcription factor Nanog (NANOG), suggesting that a decrease in MPC expression promotes the Warburg effect and the maintenance of stemness in colon cancer cells.