Other similar works found that extracellular HMGB1 can act extrinsically on its membrane receptor TLR-4 to facilitate the signaling of pro-survival factors in neuroblastoma [64], and HMGB1/TLR-4 signaling would be activated to inhibit cell apoptosis in cortex of rats with brain injury [65]. The gene discussed is TLR4; the disease is neuroblastoma.