Several proteins (CXCL11, EIF5A, STAT1, CA13, ISG15, FSTL3, FN1, HIST1H1C, CST3, CTSV, PCSK9, and MDK) were similarly dysregulated in the gastrointestinal, astrocytoma, kidney and Sertoli cell types. The gene discussed is ISG15; the disease is astrocytoma (excluding glioblastoma).