Breast cancer cells grown on an orbital shaker at 60 rpm, equivalent to 4.5 dyn/cm2, increased the production of ROS and reactive nitrogen species [31] upregulating ROS-responsive genes such as Sod1, Cat, Nox1, and Gpx1 and NO-responsive genes such as Nos1 and Nos2 [31]. This evidence concerns the gene CAT and breast carcinoma.