LAT and viral infectious disease: After the vaginal challenge, there was no significant difference in the viral load in the brain tissue from days 1–5 in all three groups, but on the seventh day of virus infection when the mice began to die, the viral loads of the tissues in the RL1-LAT-HSV-2 group were two orders of magnitude lower than those in the wild-type virus group and one order of magnitude lower than those in the LAT-HSV-2 group (Figure 3a).