Barbarisi M. et al. tested a nano-HG of HA loaded with the flavonoid Q [50], in order to improve its GBM cell internalization and increase the cytotoxicity of the alkylating drug temozolomid, as studied in two GBM cell lines with different O638-methylguananine-DNA methyltransferase (MGMT) expression levels (A172 and T98MG cells, having low and high MGMT expression levels, respectively). This evidence concerns the gene MGMT and glioblastoma.