Hepatic phosphoenolpyruvate carboxy-kinase (PEPCK), glucokinase (GK), and glucose-6-phosphate (G6pase) activities were significantly decreased in the ALL group, and hepatic glycogen levels were also lowered in the ALL group compared to HFD and ERY group (Figure 2D). The gene discussed is G6PC1; the disease is acute lymphoblastic leukemia.