HMGCR and acute lymphoblastic leukemia: The ALL group also showed significantly decreased lipid metabolism-related enzymatic activities, including fatty acid synthase (FAS), β-oxidation, β-hydroxy-β-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, and acyl-CoA: cholesterol acyltransferase-1 (ACAT) Figure 3C. In accordance with these results, the morphological observations of lipid formation in the liver tissue showed reduced lipid droplet formation in the liver of the ALL group (Figure 3E).