More recently, we have published on the association between ABCG2 mRNA expression and irinotecan effects in the PETACC-3 prospective randomized clinical trial [13], where patients with stage III colon cancer were randomized to adjuvant 5FU/LV or 5FU/LV and irinotecan [8]. The gene discussed is ABCG2; the disease is malignant colon neoplasm.