CHEK2 and cancer: Recently, using targeted sequencing to screen 94 genes associated with inherited cancer predisposition in a series of 121 early-onset/familial PrCa patients, Paulo et al. [89] identified potentially pathogenic PrCa predisposing germline variants in 14.9% of the cases, with the most commonly mutated genes being ATM (5.8%) and CHEK2 (3.3%), altogether representing 61.1% of the identified carriers.