HOXB13 and pure red-cell aplasia: In fact, most of the genes contributing to an inherited predisposition to PrCa were identified by the observed occurrence of PrCa cases in families with known hereditary cancer syndromes, namely hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) [28,29,30], with only the HOXB13 gene being specifically associated with an increased risk of HPC [31].