PRPF3 and infection: In the current study, we report the daily body weight and rectal temperature of all infected guinea pigs in Figure 1, which shows that the majority of both the parental P18- and recombinant rP18-infected guinea pigs reached terminal points for euthanization at day 14 post infection (pi) and day 18 pi, respectively, whereas a small number of animals within these groups were alive and seemed healthy at the end point of the experiments (i.e., 18 dpi) when these animals were humanely euthanized.