In line with this role of PPARα, the L162V Pparα gene polymorphism, which results in a PPARα variant with lower transcriptional activity, is associated with increased serum levels of triglycerides (TGs), total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein (apo) A1 and apoB [46,47,48,49,50], influencing the onset and progress of type 2 diabetes (T2D) [51,52]. This evidence concerns the gene PPARA and type 2 diabetes mellitus.