Lastly, the activation of PPARβ/δ by GW0742 protects skeletal muscle against metabolic disorders caused by chronic exposure to a high concentration of sugars by affecting the insulin and inflammatory cascades, including reversal of the diet-induced activation of NF-κB and the expression of both iNOS and intercellular adhesion molecule 1 [653]. The gene discussed is PPARD; the disease is Other metabolic disease.