STAT3 and osteosarcoma: Therefore, an investigation on osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition showed that pectolinarigenin inhibited constitutive and interleukin-6-induced STAT3 signaling, decreased the accumulation of STAT3 in the nucleus and blocked STAT3 DNA-binding activity in osteosarcoma cells, as well as disturbing the DNMT1/HDAC1/STAT3 complex formation in a SHP-1 promoter site, therefore, releasing the transcription repression of SHP-1.