ENPP6 and amyotrophic lateral sclerosis: Furthermore, ectonucleotide pyrophosphatase/phosphor-diesterase family member 6 (ENPP6) has been determined to be downregulated in SOD1G93A mouse spinal cord samples and in ALS lumbar spinal cords through both gene expression and proteomic analysis [83,84], which is consistent with its expression in the ALS MCEVs.