MAPT and tauopathy: Of interest, recently developed ultrasensitive technologies based on the aggregation properties of different pathologic seed of tau and αSyn, like Real Time Quaking Induced Conversion assay (RT-QuIC), developed in the field of prion diseases, and Protein misfolding cyclic amplification (PMCA), are promising tools in detecting pathological aggregates in CSF, brain and olfactory mucosa homogenates for the diagnosis of several synucleinopathies and tauopathies [282,283,284].