For example in PSP, different from AD, pathological tau accumulations start in the neurons of subcortical and brainstem nuclei, in the oligodendrocytes of the globus pallidus, and in the astrocytes of the striatum, followed by tau accumulation in cortical astrocytes, neurons, and oligodendrocyte, respectively, with a fronto-parietal to temporal to occipital sequence [177]. Here, MAPT is linked to Alzheimer disease.