There was no significant difference in initial prostate-specific antigen (PSA) level, Gleason score, clinical tumor stage, NCCN risk classification, ADT, fractional PBT dose, CTV, IPSS total score, severity of IPSS, LUTS medication use before PBT, diabetes, or anti-coagulant therapy among these three groups (Table 1). This evidence concerns the gene KLK3 and diabetes mellitus.