Furthermore, evidence in mouse models showed that K-RAS-dependent signaling activated CAFs through the induction of Hedgehog ligands, regulated extracellular matrix (ECM) remodeling, and promoted collagen degradation by matrix metalloproteinases (MMPs), facilitating angiogenesis, tumor cells invasion, and metastasis [17,18,80,82,83]. Here, KRAS is linked to neoplasm.