As previously reported, cancer cells with high α-Sma expression show enhanced metastasis and poor prognosis in lung adenocarcinoma [23] and higher expression of α-Sma was detected in malignant ovarian epithelial neoplasms than in the benign tumors [24], suggesting cancer cells with high α-Sma expression may be more aggressive. The gene discussed is ACTA1; the disease is benign neoplasm.