With the regulation of the tumor microenvironment, more genes were upregulated with over two-fold differences in both HK1 and C17 xenografts after CYLD knockout, including BCL2A1, CXCL1, BIRC3, SERPINB2, total VEGF, TNFA, and VEGFA (Figure 4F). The gene discussed is CYLD; the disease is neoplasm.