Histone deacetylases (HDACs), histone methyltransferases (HMTs as EZH2) and the family of BET (bromodomain and extra-terminal domain) seem to be the most involved in the cancer process, but histone acetyltransferases (HATs) and histone demethylases (HDMs) can also be deregulated in cancers [60]. This evidence concerns the gene PRDM9 and cancer.