MAPK inhibitors, such as BRAF inhibitors (e.g., vemurafenib, dabrafenib, and encorafenib), MEK inhibitors (e.g., cobimetinib, trametinib, and binimetinib), or their combination, are beneficial for most melanoma patients with tumor carrying activating V600E/K mutation in the BRAF oncogene [1]. This evidence concerns the gene BRAF and neoplasm.