SERPINF2 and melanoma: In addition, the genes overexpressed in SKMel28R cells and downregulated by Api correlated with an invasive phenotype of melanoma cells, as confirmed by gene-expression analysis in melanoma cell lines from the dataset of Verfaillie et al. (GSE60664 [16]), depending on their proliferative (green) or invasive state (red) (Figure 5d, right).