MIF and dengue disease: The interesting finding in the study of Martin et al. was that EVs, released by mdDCs infected with DENV3-5532, contain mRNAs of cytokines, such as CXCR4, macrophage migration inhibitory factor (MIF), IL-17A, and IL-8, involved in the disease severity in dengue patients and platelet and endothelial cell activation, and cytokines associated with plasma leakage and Dengue Shock Syndrome, such as IL-6, which coincides with the hemorrhagic manifestations in DENV3-5532 infected patients [9].