Additionally, the mRNAs (IFNB1, IFNL2, RIG-I (DDX58), TRIM25, MDA5 (IFIH1), IRF1, IRF9, STAT2, ISG15, ISG54 (IFIT2), and OAS1) contained in EVs from the WNV-infected A549 cells or induced during flavivirus infection are associated with the antiviral response mediated by the type I IFN signaling pathway, Wnt signaling, Jak/STAT cascade, and T cell receptor signaling pathway [11]. The gene discussed is RIGI; the disease is Flavivirus Infections.