Furthermore, EVs isolated from PBMCs treated with IFN-α can inhibit DENV3-5532 infection in PBMCs, suggesting that EVs could be a communication pathway between immune cells to share defense signals during flavivirus infection to inhibit viral replication and reduce viral infection, as shown in Figure 1 and Figure 5 [9]. This evidence concerns the gene IFNA17 and Flavivirus Infections.