Moreover, exosomes from WNV-infected A549 cells contained HSP70, the tetraspanins CD9 and CD63 [11], and the mRNA, which encodes DDX58 [9,11], which plays an essential role in the host restriction of flavivirus infection, as shown in Figure 1 and Figure 5 [50,51]. The gene discussed is RIGI; the disease is Flavivirus Infections.