Single-cell RNA seq analysis of peripheral blood mononuclear cells (PBMCs) from septic patients identified 6 monocyte subsets (CD14+ NEAT1+ SELL+ monocyte, CD14+ NEAT1+ CCR1+ monocyte, NEAT1+ CD163+ monocyte, CCL3L1+ monocyte, CD16+ monocyte, monocytes/macrophage), of which the NEAT1high monocytes were significantly expanded specifically during sepsis, indicating that high expression of NEAT1 can potentially be used as a diagnostic biomarker of sepsis [100]. This evidence concerns the gene NEAT1 and Sepsis.