Furthermore, a study on an immunocompetent patient with pulmonary cryptococcosis showed that although the patient had no apparent immune disorder, monocytes isolated from the peripheral blood manifested a significant reduction in killing activity against C. neoformans, as well as a significant impairment in TNF-α, interleukin 1 beta (IL-1β), and nitric oxide production [63]. The gene discussed is IL1B; the disease is immune system disorder.