HMOX1 and coronary artery disorder: Regarding the dual role of HO-1 for cellular viability, it has also been suggested to use the CRISPR/dCas9 system to activate cellular HO-1 expression to an optimal level, which for example guarantees the survival of transplanted stem cells in patients with ischemic heart disease without triggering the cytotoxic effects associated with excessive HO-1 expression [62].