However, suppression of IGF2/IR/IGF-1R inhibits the metastatic ability and tumor growth of erlotinib-resistant CC cells in vivo and in vitro, and linstinib-mediated IGF-1R inhibition also markedly suppressed the proliferation of human liver myofibroblasts (HLMF) through reduction of α-SMA [58]. This evidence concerns the gene INSR and cholangiocarcinoma.