Other mutants of EBBB3 (V1035D, G508R, G582W, A1252S, D581N, R444Q, V586M, G994D, N222Tfs*47, E230Dfs*39, D73Tfs*11, D296Ifs*16, D297Ifs*16) and ERBB4 (R103C, I68N, L432M, S602C, P1158H, T475A, S1286Lfs*5, F356Sfs*2) were identified in patients with BTC, including CC, but their function is unknown (TCGA dataset) [110,111]. Here, ERBB4 is linked to cholangiocarcinoma.