EGFR, COX-2, AKT, and p-MAPK were significantly upregulated in patients with CC (62.5% (15/23), 100% (23/23), 95.8% (23/24), and 87% (20/23), respectively), and these expression patterns exhibit a significant correlation between EGFR and AKT expression in these patients [81]. This evidence concerns the gene EGFR and cholangiocarcinoma.