It was also shown that 15% (6/40) of patients with CC had point mutations in the tyrosine kinase domain of the EGFR of patients with ICC (K575R, E872K, T790M), ECC (C775Y, G882S, V843I, L858R), and GBC (A864T). This evidence concerns the gene EGFR and intrahepatic cholangiocarcinoma.