EGFR and cholangiocarcinoma: Merlin, the neurofibromatosis type 2 (Nf2) tumor suppressor, inhibits activation of EGFR and suppresses the internalization of EGFR by NHE-RH1-mediated Merlin-EGFR association, which subsequently leads to the proliferation of CC cells by preventing the formation of EGFR complexes with its targets [96].