EGFR and neoplasm: Furthermore, loss of NRP-1 induces cell cycle arrest at phase G1/S by suppressing cyclin E and cyclin-dependent kinase (CDK)2 and inducing p27, and it inhibits tumor metastasis and growth in vivo and in vitro by inhibiting activation of the VEGF/VEGFR, EGF/EGFR, and HGF/c-Met pathways [61].