These proteins have been reported to have a close correlation with lymph node metastasis as ERBB2 and c-Met were positive in 76% (19/25) and 16% (4/25) of metastatic lymph nodes in patients with ICC, and high c-MET expression was significantly correlated with poor survival of these patients [21]. This evidence concerns the gene MET and metastatic malignant neoplasm in the lymph nodes.