In accordance with our findings, among the identified hub genes, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), fibroblast growth factor receptor (FGFR), ErbB receptor tyrosine kinase ERBB3 and ERBB4, mammalian target of rapamycin (mTOR), and the ER gene ESR1 have been reported to be either somatic mutated or have frequently altered expression in IBC tumors [47,48]. This evidence concerns the gene PIK3CA and inflammatory breast carcinoma.