A study by Ye and coworkers [66] presented evidence that overexpression of E-cadherin in IBC is driven by altered protein trafficking and demonstrated that the human xenograft models of IBC, MARY-X and MARY-X spheroids, displayed downregulated E-cadherin mRNA levels, whereas they overexpressed its protein levels in comparison to E-cadherin-positive human breast carcinoma cells. The gene discussed is CDH1; the disease is breast carcinoma.