Returning to the comparisons of cancers detected by the SIG-DESNT and SIG-HES6 groups of signatures, we combined data from the CancerMap, CamCap and MSKCC datasets (n = 482 patients) with PSA failure as an end point, and then separately applied the DESNT, HES6, NMF1, and Prolaris tests. The gene discussed is HES6; the disease is cancer.