As shown in Figure 7, adipose tissue in 25-week-old α7−/− mice had significantly higher expression of genes encoding for TNFα, IL-6, F4/80 and IL-15 as well as CXCL1 (Figure 7a), which are associated with obesity [39,40]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.